The research aims at the development of metal, ceramics or ceramics-coated metal implants with enhanced biomineralization properties. The latter is achieved by the implementation of well-controlled nano-scale topography on the surface of the implant, using a number of different nanotechnological methods. The scientific goal is a detailed understanding of the effects on platelet adhesion and inflammatory response on bone formation and implant integration. Cells are very sensitive to the surface topographical and physico-chemical environment and recognize nanometer-size alterations, which subsequently can induce changes in the cytoskeleton, cell shape, phagocytotic activity, and cytokine expression.